When you hear MAO-B inhibitors, a class of drugs that block the monoamine oxidase B enzyme to increase dopamine levels in the brain. Also known as dopamine-preserving agents, they’re not just for symptom relief—they’re one of the few treatments that may actually slow how fast Parkinson’s disease progresses. Unlike painkillers or antidepressants that mask how you feel, MAO-B inhibitors work on the root issue: low dopamine. This is why they’re often among the first prescriptions given to people newly diagnosed with Parkinson’s.
Two of the most common MAO-B inhibitors, drugs designed to prevent the breakdown of dopamine in the brain. Also known as dopamine enhancers, they are selegiline and rasagiline. Selegiline comes in oral pills or a patch, while rasagiline is taken once daily. Both are used alone in early Parkinson’s or added to levodopa later to smooth out motor fluctuations. They’re not magic bullets—side effects like insomnia or dizziness can happen—but they’re far gentler than many other neurological drugs. And unlike some treatments, they don’t cause sudden crashes or require frequent dose changes.
These drugs also show up in studies on cognitive decline and depression, especially in older adults. While not FDA-approved for those uses, some doctors prescribe them off-label when standard options fail. That’s because dopamine isn’t just about movement—it affects mood, focus, and even motivation. If you’ve ever felt mentally foggy after years of Parkinson’s, or noticed your energy dipping even with good meds, MAO-B inhibitors might be part of the answer. They’re not for everyone, but for many, they’re the quiet backbone of long-term brain health.
What you’ll find below are real-world comparisons, patient stories, and practical insights on how these drugs fit into daily life. Some posts talk about switching from one MAO-B inhibitor to another. Others compare them with levodopa or newer therapies. You’ll see how people manage side effects, what works when meds lose their punch, and how diet or sleep habits can make a difference. This isn’t theory. It’s what people are actually doing to stay in control.
A detailed side‑by‑side comparison of the Emsam selegiline patch with oral MAO‑B inhibitors, phenelzine, sertraline, and venlafaxine, covering efficacy, safety, cost, and when to choose each.
